Colorectal Cancer is Increasing Rapidly: A Special Gene Can Help in Early Detection – Explained
Colorectal cancer (CRC), which affects the colon or rectum, is one of the fastest-growing cancers globally. Alarming trends show a rise in cases, especially among younger adults. However, scientific advancements are giving hope — a special gene or biomarker may help detect colorectal cancer early, increasing the chances of survival and effective treatment.
🔬 Why is Colorectal Cancer Increasing?
- Unhealthy diet (high in red meat, processed foods, low in fiber)
- Sedentary lifestyle and obesity
- Smoking and alcohol consumption
- Environmental toxins and pollutants
- Delayed screening, especially in younger populations
- Genetic predisposition or family history
🧬 The Role of Genes in Early Detection
Scientists have identified biomarker genes that show changes even before cancer becomes advanced. One such “special gene” commonly researched is SEPT9, among others.
🧠 Let’s understand how it works:
- SEPT9 Gene & DNA Methylation:
- In colorectal cancer, the SEPT9 gene becomes hypermethylated, which can be detected through a blood test.
- A test called “Epi proColon” has been approved in some countries for detecting methylated SEPT9 DNA — even in early stages of CRC.
- Liquid biopsy:
- Instead of invasive colonoscopy, a simple blood test can now detect cancer-related genetic material in circulation.
- These tests look for circulating tumor DNA (ctDNA) and genetic mutations like KRAS, APC, TP53 associated with colorectal cancer.
- Personalized risk assessment:
- Genetic screening helps identify people with inherited gene mutations, such as Lynch syndrome (MLH1, MSH2) or FAP (APC gene) — increasing lifetime CRC risk.
- This allows earlier and more frequent screening in high-risk groups.
✅ Benefits of Genetic Detection
- Early diagnosis before symptoms appear
- Non-invasive tests (like blood or stool-based DNA tests)
- Better survival rate if caught early
- Targeted treatment based on genetic mutations
- Family screening for inherited risk
🌍 What Can You Do?
- Don’t ignore symptoms like blood in stool, unexplained weight loss, or chronic constipation
- If you’re over 45 or have a family history, get screened regularly
- Ask your doctor about genetic testing if CRC runs in your family
- Maintain a high-fiber, plant-based diet, regular exercise, and avoid smoking
🧾 In Summary
Colorectal cancer is rising, but genetic markers like the SEPT9 gene are revolutionizing how early we can detect it. With better screening methods and awareness, it’s possible to catch this silent disease before it becomes life-threatening.
